| Identification | Back Directory | [Name]
Nicanartine | [CAS]
150443-71-3 | [Synonyms]
Nicanartine
2,6-di-tert-butyl-4-(3-(pyridin-3-ylmethoxy)propyl)phenol
Phenol, 2,6-bis(1,1-dimethylethyl)-4-[3-[(3-pyridinyl)methoxy]propyl]- | [Molecular Formula]
C23H33NO2 | [MDL Number]
MFCD00867555 | [MOL File]
150443-71-3.mol | [Molecular Weight]
355.51 |
| Hazard Information | Back Directory | [Uses]
Nicanartine, an orally active antioxidant and lipid-lowering compound, is an antiatherogenic drug. Nicanartine inhibits the oxidation of low-density lipoprotein (LDL). | [in vivo]
Nicanartine inhibits smooth muscle cell proliferation after balloon catheter-induced endothelial injury and improves vascular reactivity as reflected by an increased response to acetylcholine-induced dilatation in cholesterol-fed and Watanabe rabbits[1]. | [References]
[1] Hammes HP, et al. Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine. Diabetologia. 1997 Jun;40(6):629-34. DOI:10.1007/s001250050726
[2] H P Hammes, et al. Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine. Diabetologia. 1997 Jun;40(6):629-34. DOI:10.1007/s001250050726 |
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