| Identification | Back Directory | [Name]
S-Amlodipine | [CAS]
150566-71-5 | [Synonyms]
LEVAMLODIPINE BESYLATE，S-Amlodipine
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, monobenzenesulfonate | [Molecular Formula]
C26H31ClN2O8S | [MDL Number]
MFCD07773085 | [MOL File]
150566-71-5.mol | [Molecular Weight]
567.051 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO : ≥ 150 mg/mL (264.53 mM) | [form ]
Solid | [color ]
White to light yellow | [InChIKey]
ZPBWCRDSRKPIDG-VOPAOICTNA-N | [SMILES]
O=S(=O)(O)C1=CC=CC=C1.O=C(OCC)C1[C@@H](C2=C(Cl)C=CC=C2)C(C(=O)OC)=C(C)NC=1COCCN |&1:16,r| |
| Hazard Information | Back Directory | [Uses]
Levamlodipine Besylate is the (S)-Enantiomer salt of Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer. | [in vivo]
Levamlodipine besylate (0.1, 0.5 mg/kg, once daily; 8 weeks; p.o.) can restore hippocampal Ca2+/CaM dependent protein kinase II (CaMKII) and alleviate hippocampal dependent spatial cognitive impairment in vascular dementia mice[1].
Levamlodipine besylate (1 mg/kg, once daily; 16 weeks; p.o.) can lower blood pressure and protect organs in spontaneously hypertensive rats[3]. | Animal Model: | Spontaneously hypertensive rats (SHR)[3]. | | Dosage: | 1 mg/kg | | Administration: | Oral gavage (p.o.); once daily; 16 weeks | | Result: | Reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP), reduced heart and aortic hypertrophy, increased kidney weight to prevent kidney atrophy. |
| Animal Model: | VaD mice model of right unilateral common carotid arteries occlusion (rUCCAO)[1]. | | Dosage: | 0.1, 0.5 mg/kg | | Administration: | Oral gavage (p.o.); once daily; 8 weeks | | Result: | Recovered phosphorylated CaMKII (Thr286) levels in the hippocampus and improved cognitive impairment in mice. |
| [storage]
-20°C, protect from light |
|
| Company Name: |
Prudence Pharma Chem
|
| Tel: |
+91-9624042444 +91-9825205460 |
| Website: |
www.prudencepharma.com |
|