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150566-71-5

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150566-71-5 Structure

150566-71-5 Structure
IdentificationBack Directory
[Name]

S-Amlodipine
[CAS]

150566-71-5
[Synonyms]

LEVAMLODIPINE BESYLATE，S-Amlodipine
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, monobenzenesulfonate
[Molecular Formula]

C26H31ClN2O8S
[MDL Number]

MFCD07773085
[MOL File]

150566-71-5.mol
[Molecular Weight]

567.051
Chemical PropertiesBack Directory
[storage temp. ]

-20°C, protect from light
[solubility ]

DMSO : ≥ 150 mg/mL (264.53 mM)
[form ]

Solid
[color ]

White to light yellow
[InChIKey]

ZPBWCRDSRKPIDG-VOPAOICTNA-N
[SMILES]

O=S(=O)(O)C1=CC=CC=C1.O=C(OCC)C1[C@@H](C2=C(Cl)C=CC=C2)C(C(=O)OC)=C(C)NC=1COCCN |&1:16,r|
Hazard InformationBack Directory
[Uses]

Levamlodipine Besylate is the (S)-Enantiomer salt of Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.
[in vivo]

Levamlodipine besylate (0.1, 0.5 mg/kg, once daily; 8 weeks; p.o.) can restore hippocampal Ca2+/CaM dependent protein kinase II (CaMKII) and alleviate hippocampal dependent spatial cognitive impairment in vascular dementia mice[1]. Levamlodipine besylate (1 mg/kg, once daily; 16 weeks; p.o.) can lower blood pressure and protect organs in spontaneously hypertensive rats[3].

Animal Model:Spontaneously hypertensive rats (SHR)[3].
Dosage:1 mg/kg
Administration:Oral gavage (p.o.); once daily; 16 weeks
Result:Reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP), reduced heart and aortic hypertrophy, increased kidney weight to prevent kidney atrophy.
Animal Model:VaD mice model of right unilateral common carotid arteries occlusion (rUCCAO)[1].
Dosage:0.1, 0.5 mg/kg
Administration:Oral gavage (p.o.); once daily; 8 weeks
Result:Recovered phosphorylated CaMKII (Thr286) levels in the hippocampus and improved cognitive impairment in mice.
[storage]

-20°C, protect from light
Spectrum DetailBack Directory
[Spectrum Detail]

Levamlodipine Besylate(150566-71-5)1HNMR
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