| Identification | Back Directory | [Name]
5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | [CAS]
1507370-54-8 | [Synonyms]
BCN-PEG4-HyNic
5,8-Dioxa-2,11-diazadodecanoic acid, 12-[6-[2-(1-methylethylidene)hydrazinyl]-3-pyridinyl]-12-oxo-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | [Molecular Formula]
C26H37N5O5 | [MDL Number]
MFCD34470199 | [MOL File]
1507370-54-8.mol | [Molecular Weight]
499.61 |
| Hazard Information | Back Directory | [Uses]
BCN-PEG4-HyNic is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG4-HyNic is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Acid Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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