ChemicalBook--->CAS DataBase List--->1509928-04-4

1509928-04-4

1509928-04-4 Structure

1509928-04-4 Structure
IdentificationBack Directory
[Name]

Istiratumab
[CAS]

1509928-04-4
[Synonyms]

Istiratumab
Research Grade Istiratumab (DHC29907)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers[1][2][3].
[References]

[1] Kundranda M, et al. Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE). Ann Oncol. 2020 Jan;31(1):79-87. DOI:10.1016/j.annonc.2019.09.004
[2] Camblin AJ, et al. Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer. Clin Cancer Res. 2018 Jun 15;24(12):2873-2885. DOI:10.1158/1078-0432.CCR-17-2262
[3] Camblin AJ, et al. Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer. Sci Rep. 2019 Nov 14;9(1):16832. DOI:10.1038/s41598-019-53322-y
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