| Identification | Back Directory | [Name]
Betamethasone 21-phosphate disodium | [CAS]
151-73-5 | [Synonyms]
bentelan
betnesol
Celestan
Bentalan
NSC 90616
Durabetason
Vista-Methasone
Betamethasone 21-pho
BETAMETHASONE SODIUM PHOSPHATE
betamethasonedisodiumphosphate
BETMETHASONE DISODIUM PHOSPHATE
BETAMETHASONESODIUMPHOSPHATE,USP
betamethasone 21-phosphate sodium
Disodium betamethasone 21-phosphate
BETAMETHASONE 21-DISODIUM PHOSPHATE
betamethasone 21-phosphate disodium
21-(dihydrogenphosphate),disodiumsalt
BETAMETHASONE 21-PHOSPHATE SODIUM SALT
Betamethasone Sodium Phosphate (500 mg)
BETAMETHASONE 21-PHOSPHATE DISODIUM SALT
9a-fluoro-16b-methylprednisolone-21-(disodium phosphate)
Betamethasone Sodium Phosphate (500 mg)K0C3580.993mg/mg(an)
20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-pregna-4-diene-3
9-Fluoro-11β,17-dihydroxy-16β-methyl-21-[bis(sodiooxy)phosphinyloxy]pregna-1,4-diene-3,20-dione
9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphoric acid disodium salt
(11β,16β)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione SodiuM Salt
1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT
9-Fluoro-11β,17,21-trihydroxy-16β-Methylpregna-1,4-diene
-3,20-dione 21-(Dihydrogen Phosphate) SodiuM Salt
Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,DisodiumSalt,(11Beta,16Beta)-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI) | [EINECS(EC#)]
205-797-0 | [Molecular Formula]
C22H28FNa2O8P | [MDL Number]
MFCD00200361 | [MOL File]
151-73-5.mol | [Molecular Weight]
516.4 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder, very hygroscopic. | [Melting point ]
206-211°C | [alpha ]
+98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis) | [storage temp. ]
room temp | [solubility ]
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. | [form ]
neat | [color ]
White to Off-White | [PH]
7.5～9.0(5g/l, 25℃) | [Water Solubility ]
water: 50mg/mL, clear to very slightly hazy, faintly yellow | [Merck ]
14,1180 | [Stability:]
Hygroscopic | [InChIKey]
PLCQGRYPOISRTQ-LWCNAHDDSA-L | [SMILES]
[C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r| | [EPA Substance Registry System]
Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17-dihydroxy-16- methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-(151-73-5) |
| Hazard Information | Back Directory | [Uses]
A Betamethasone | [Uses]
An anti-inflammatory agent | [Uses]
antiinflammatory, glucocorticoid | [Uses]
Nasal, Ophthalmic, Oral, Parenteral | [Definition]
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate. | [Chemical Properties]
White or almost white powder, very hygroscopic. | [Brand name]
Celestone (Schering). | [Biochem/physiol Actions]
Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis. | [Safety Profile]
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS07,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H302-H360FD-H373 | [Precautionary statements ]
P202-P260-P264-P270-P301+P312-P308+P313 | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
36 | [WGK Germany ]
3
| [RTECS ]
TU4056500
| [HS Code ]
29372290 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Oral
Repr. 1B
STOT RE 2 | [Toxicity]
LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90 |
| Questions And Answer | Back Directory | [Indications and Usage]
Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
| [Mechanisms of Action]
Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy. | [Contraindications]
Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris. | [Category]
Toxic | [Toxicity level]
Medium | [Acute toxicity]
Oral administration - mice LD50: >4500 mg/kg | [Flammability]
Flammable; produces toxic fluoride fumes | [Storage and transport]
Store in a cool, ventilated, and dry place | [Extinguishing agents]
Dry powder, foam, sand, carbon dioxide, mist |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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