| Chemical Properties | Back Directory | [Boiling point ]
627.2±55.0 °C(Predicted) | [density ]
1.486±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.40±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
BAY-Y 3118 is a new chlorofluoroquinolone with antimicrobial activity. | [in vivo]
Immunocompetent mice are rapidly cured by treatment with 4 mg every 12 h. Concomitantly, the levels of interleukin 6 and gamma interferon in mouse sera decline rapidly. In immunocompetent mice, treatment with 2 mg of BAY-Y 3118 every 12 h results in a greater initial reduction in the listerial counts in the organs than treatment with 2 mg of ampicillin every 12 h. BAY-Y 3118 completely eliminates L. monocytogenes from the livers and spleens of chronically infected nude mice[3]. | [References]
[1] Fass RJ, et al. In vitro activity of Bay y 3118, a new quinolone. Antimicrob Agents Chemother. 1993 Nov;37(11):2348-57. DOI:10.1128/AAC.37.11.2348
[2] García I, et al. Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1994 Oct;38(10):2426-9. DOI:10.1128/AAC.38.10.2426
[3] Nichterlein T, et al. Bay Y 3118, a new quinolone derivative, rapidly eradicates Listeria monocytogenes from infected mice and L929 cells. Antimicrob Agents Chemother. 1994 Jul;38(7):1501-6. DOI:10.1128/AAC.38.7.1501 |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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