| Identification | Back Directory | [Name]
3-((benzodioxol-5-yl)methylaminocarbonyl)-1,2,3,4-tetrahydro(1)benzothieno(2.3-c)pyridine | [CAS]
151227-58-6 | [Synonyms]
AP-521 (Free base)
AP 521 (Free base),AP521 (Free base)
3-((benzodioxol-5-yl)methylaminocarbonyl)-1,2,3,4-tetrahydro(1)benzothieno(2.3-c)pyridine
[1]Benzothieno[2,3-c]pyridine-3-carboxamide, N-(1,3-benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-, (3R)- | [Molecular Formula]
C20H18N2O3S | [MDL Number]
MFCD31567470 | [MOL File]
151227-58-6.mol | [Molecular Weight]
366.43 |
| Hazard Information | Back Directory | [Uses]
AP-521 (free base) is a benzothienopyridine derivative that exhibits potent anxiolytic effects by acting as a postsynaptic 5-HT1A receptor agonist and by enhancing serotonergic neural transmission in the medial prefrontal cortex (mPFC). AP-521 (free base) is promising for research of anxiety disorders[1]. | [References]
[1] Kasahara K, et al. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. J Pharmacol Sci. 2015 Jan;127(1):109-16. DOI:10.1016/j.jphs.2014.11.008 |
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