| Identification | Back Directory | [Name]
CVS 738 | [CAS]
151275-15-9 | [Synonyms]
CVS 738
L-Prolinamide, N-(1-oxo-2-propylpentyl)-L-α-aspartyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]- (9CI) | [Molecular Formula]
C23H40N6O6 | [MOL File]
151275-15-9.mol | [Molecular Weight]
496.6 |
| Hazard Information | Back Directory | [Description]
Cvs 738 is the desmethyl form of CVS 1123, an orally bioavailable thrombin inhibitor. | [Uses]
CVS 738 is the desmethyl form of CVS 1123, which is also the major active metabolite of CVS 1123[1][2]. | [References]
[1] Mendoza CB, et al. Quantitation of an orally available thrombin inhibitor in rat, monkey and human plasma and in human urine by high-performance liquid chromatography and fluorescent post-column derivatization of arginine. J Chromatogr A. 1997 Feb 21;762(1-2):299-310. DOI:10.1016/s0021-9673(96)00865-5
[2] Rebello S S, et al. CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury[J]. Journal of cardiovascular pharmacology, 1997, 29(2): 240-249. DOI:10.1097/00005344-199702000-00013 |
|
|