| Identification | Back Directory | [Name]
Carbamic acid, N-(2-butyl-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-6-yl)-, 1,2-dithiolan-4-yl ester | [CAS]
1513848-14-0 | [Synonyms]
TRFS-green
Carbamic acid, N-(2-butyl-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-6-yl)-, 1,2-dithiolan-4-yl ester | [Molecular Formula]
C20H20N2O4S2 | [MDL Number]
MFCD34469562 | [MOL File]
1513848-14-0.mol | [Molecular Weight]
416.51 |
| Chemical Properties | Back Directory | [Boiling point ]
582.3±50.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.20±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TRFS-green is a highly selective off?on fluorescent probe for imaging selenoprotein thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. After it is activated by TrxR, the maximum absorbance shifts to around 440 nm[1]. | [References]
[1] Liangwei Zhang, et al. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells. J Am Chem Soc. 2014 Jan 8;136(1):226-33. DOI:10.1021/ja408792k
[2] Xinming Li, et al. A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun. 2019 Jun 21;10(1):2745. DOI:10.1038/s41467-019-10807-8 |
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