| Identification | Back Directory | [Name]
L-162 313 | [CAS]
151488-11-8 | [Synonyms]
L162 L-162 L 162 5,7-dimethyl-2-ethyl-3-[[4-[2--(n-butyloxycarbonyl-sulfon-amido)-5-isobutyl-3-thienyl]-phenyl]-methyl]-imidazo-[4,5-b]-pyridine Carbamic acid, N-[[3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester | [Molecular Formula]
C30H38N4O4S2 | [MDL Number]
MFCD00915204 | [MOL File]
151488-11-8.mol | [Molecular Weight]
582.78 |
| Chemical Properties | Back Directory | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10 mg/mL, soluble | [form ]
solid | [pka]
4.32±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth[1]. | [Biochem/physiol Actions]
Non-peptide AT1 receptor agonist. | [References]
[1] Wan Y, et al. First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. J Med Chem. 2004 Mar 11;47(6):1536-46. DOI:10.1021/jm031031i |
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