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151488-11-8

151488-11-8 Structure

151488-11-8 Structure
IdentificationBack Directory
[Name]

L-162 313
[CAS]

151488-11-8
[Synonyms]

L162
L-162
L 162
5,7-dimethyl-2-ethyl-3-[[4-[2--(n-butyloxycarbonyl-sulfon-amido)-5-isobutyl-3-thienyl]-phenyl]-methyl]-imidazo-[4,5-b]-pyridine
Carbamic acid, N-[[3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester
[Molecular Formula]

C30H38N4O4S2
[MDL Number]

MFCD00915204
[MOL File]

151488-11-8.mol
[Molecular Weight]

582.78
Chemical PropertiesBack Directory
[density ]

1.26±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 10 mg/mL, soluble
[form ]

solid
[pka]

4.32±0.10(Predicted)
[color ]

white
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth[1].
[Biochem/physiol Actions]

Non-peptide AT1 receptor agonist.
[References]

[1] Wan Y, et al. First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. J Med Chem. 2004 Mar 11;47(6):1536-46. DOI:10.1021/jm031031i
Spectrum DetailBack Directory
[Spectrum Detail]

L-162 313(151488-11-8)1HNMR
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