| Identification | Back Directory | [Name]
5-ETHYL-2'-DEOXYURIDINE | [CAS]
15176-29-1 | [Synonyms]
edu
EUdR
Etudr
aedurid
edoxudin
RWJ 15817
Epoxudine
ORF 15817
EDOXUDINE
Aids021723
Aids-021723
5-Ethyl-durd
5-ethyldeoxyuridine
2’-deoxy-5-ethyl-uridin
2’-deoxy-5-ethyluridine
5-ETHYL-2'-DEOXYURIDINE
beta-5-ethyldeoxyuridine
Uridine, 2'-deoxy-5-ethyl-
5-ETHYL-2'-DEOXYURIDINE USP/EP/BP
5-Ethyl-2’-deoxyuridine, Edoxudine (EUDR), | [EINECS(EC#)]
239-226-1 | [Molecular Formula]
C11H16N2O5 | [MDL Number]
MFCD00079191 | [MOL File]
15176-29-1.mol | [Molecular Weight]
256.26 |
| Chemical Properties | Back Directory | [Melting point ]
152-153° | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) | [form ]
Solid | [pka]
9.98(at 25℃) | [color ]
Pale Beige to Beige | [biological source]
synthetic (organic) | [Water Solubility ]
water: 50mg/mL, clear, colorless to yellow | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1 | [InChIKey]
XACKNLSZYYIACO-DJLDLDEBSA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=C(CC)C(=O)NC2=O)C[C@@H]1O |
| Hazard Information | Back Directory | [Chemical Properties]
Edoxudine is solid
| [Uses]
antiallergic, mast cell degranulation inhibitor, angiogenesis blocker | [Uses]
Edoxudine was found to be a modulator of both antitumor action and pharmacokinetics of 5-Fluorouracil (F596000), a potent antineoplastic agent in clinical use.
| [Definition]
ChEBI: Edoxudine is a pyrimidine 2'-deoxyribonucleoside. | [Biochem/physiol Actions]
5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels. | [storage]
Store at -20°C |
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