| Identification | Back Directory | [Name]
AMFONELIC ACID | [CAS]
15180-02-6 | [Synonyms]
NCA
WIN-25978
Amfonelic
NSC-100638
15180-02-6
AMFONELIC ACID
AMFONELIC ACID INCREASES DOPAMINE RE
7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic acid
Hot Selling Amfonelic Acid Powder?15180-02-6?with Best Price From Wujiaren Lab
1,8-Naphthyridine-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-7-(phenylMethyl)-
amfonelic acid (7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid) | [EINECS(EC#)]
605-001-5 | [Molecular Formula]
C18H16N2O3 | [MDL Number]
MFCD00055095 | [MOL File]
15180-02-6.mol | [Molecular Weight]
308.33 |
| Chemical Properties | Back Directory | [Melting point ]
>1000 °C | [Boiling point ]
499℃ | [density ]
1.297 | [Fp ]
256℃ | [solubility ]
0.1 M NaOH: soluble
| [form ]
powder
| [pka]
3.50±0.20(Predicted) | [color ]
yellow
| [InChI]
InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23) | [InChIKey]
WHHHJDGNBVQNAU-UHFFFAOYSA-N | [SMILES]
N1(CC)C2C(=CC=C(CC3=CC=CC=C3)N=2)C(=O)C(C(O)=O)=C1 |
| Hazard Information | Back Directory | [Description]
Amfonelic acid (AFA) is a dopamine reuptake inhibitor. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. | [Uses]
Amfonelic acid (AFA or 15180-02-6) is a dopamine reuptake inhibitor, that has marked effects on brain dopamine metabolism but not noradrenaline metabolism. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. Rats are shown to self-administer amfonelic acid in a dose-dependent manner. | [References]
The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward DOI: 10.1016/0091-3057(89)90069-5
Pharmacologic properties and mechanism of action of amfonelic acid DOI: 10.1016/0014-2999(70)90206-2
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