| Identification | Back Directory | [Name]
2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-[5,6,7,8-tetrahydro-7-oxo-8-[(phosphonooxy)methyl]-1,8-naphthyridin-3-yl]-, sodium salt (1:2), (2E)- | [CAS]
1518800-29-7 | [Synonyms]
Afabicin disodium
2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-[5,6,7,8-tetrahydro-7-oxo-8-[(phosphonooxy)methyl]-1,8-naphthyridin-3-yl]-, sodium salt (1:2), (2E)- | [Molecular Formula]
C23H25N3NaO7P | [MOL File]
1518800-29-7.mol | [Molecular Weight]
509.43 |
| Hazard Information | Back Directory | [Uses]
Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci[1]. | [References]
[1] Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015;59(5):2583-2587. DOI:10.1128/AAC.05119-14 |
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