| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, 2-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-1,6-dihydro-N-hydroxy-6-oxo- | [CAS]
1520083-61-7 | [Synonyms]
HX1
HX-1
HX 1
5-Pyrimidinecarboxamide, 2-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-1,6-dihydro-N-hydroxy-6-oxo- | [Molecular Formula]
C14H10F6N4O3 | [MDL Number]
MFCD32662441 | [MOL File]
1520083-61-7.mol | [Molecular Weight]
396.24 |
| Chemical Properties | Back Directory | [density ]
1.65±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
powder | [pka]
7.89±0.50(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Description]
HX1 is a potent reversible inhibitor of myeloperoxidase (MPO). | [Uses]
HX1 is a potent reversible myeloperoxidase (MPO) inhibitor with an IC50 value of 50 nM. HX1 is bound within the active site cavity above the heme and blocks the substrate channel. HX1 is promising for research of inflammatory diseases[1]. | [References]
[1] Forbes LV, et al. Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. J Biol Chem. 2013 Dec 20;288(51):36636-47. DOI:10.1074/jbc.M113.507756 |
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