| Identification | Back Directory | [Name]
FMRF AMIDE | [CAS]
152165-14-5 | [Synonyms]
FMRF-NH2
FMRF AMIDE
PHE-MET-ARG-PHE-NH2
PHE-MET-ARG-PHE AMIDE
H-PHE-MET-ARG-PHE-NH2
FMRFAMIDE ACETATE SALT
FMRF-AMIDE 1 1/2ACOH 2H2O
H-PHE-MET-ARG-PHE-NH2 ACOH
PHE-MET-ARG-PHE-NH2: FMRF-NH2
PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
MOLLUSCAN CARDIOEXCITATORY PEPTIDE
H-PHE-MET-ARG-PHE-NH2 ACETATE SALT
MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE
FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE
MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE ACETATE SALT
MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O | [Molecular Formula]
C29H42N8O4S | [MDL Number]
MFCD00076625 | [MOL File]
152165-14-5.mol | [Molecular Weight]
598.76 |
| Hazard Information | Back Directory | [Uses]
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons[1]. | [in vivo]
Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min[3]. | [References]
[1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0 |
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