| Identification | Back Directory | [Name]
Potassium 4-methoxysalicylate | [CAS]
152312-71-5 | [Synonyms]
MSAK
4MSK
4-MSAK
LGB-4MSK
4MS KTranexamic Acid
POTASSIUM METHOXYCINNAMATE
Potassium methoxysalicylate
POTASSIUM 4-METHOXYSALICYLATE
Potassium2-hydro-4-methoxylbenzoate
Potassium 2-hydroxy-4-methoxybenzoate
4-Methoxy Salicylic Acid Potassium Salt
P-Methoxy salicylic acid potassium salt
Benzoic acid,2-hydroxy-4-Methoxy-, potassiuM salt (1:1)
Potassium methoxysalicylate
Potassium 2-Hydroxy-4-methoxybenzoate
| [EINECS(EC#)]
200-001-8 | [Molecular Formula]
C8H7KO4 | [MDL Number]
MFCD13194966 | [MOL File]
152312-71-5.mol | [Molecular Weight]
206.24 |
| Questions And Answer | Back Directory | [Preparation]
(1) Slowly add 2,4-dihydroxybenzoic acid to an alkaline aqueous solution of sodium hydroxide, keeping the temperature below 30°C. After all the 2,4-dihydroxybenzoic acid has been added and dissolved, lower the temperature to 20°C and slowly add dimethyl sulfate dropwise, keeping the temperature below 40°C. After the addition is complete, maintain the temperature at 30-40°C for 6 hours. After the reaction is complete, raise the temperature to 60°C and stir for 30 minutes to completely decompose any unreacted dimethyl sulfate. Then lower the temperature to room temperature and adjust the pH to 1 with 10% hydrochloric acid. A large amount of white solid precipitates out. Centrifuge, wash thoroughly with deionized water, and dry to obtain crude 4-methoxysalicylic acid;
(2) Add the crude 4-methoxysalicylic acid to deionized water, heat to 80°C, stir for 0.5 hours, filter while hot, and dry to obtain pure 4-methoxysalicylic acid;
(3) In a deionized aqueous solution of potassium carbonate, heat to 50°C, slowly add 4-methoxysalicylic acid, adjust pH to 7, stop adding 4-methoxysalicylic acid, stir for 30 minutes, start recovering the solvent, cool down to crystallize, filter, and obtain crude potassium 2-hydroxy-4-methoxybenzoate;
(4) Dissolve the crude potassium 2-hydroxy-4-methoxybenzoate in a 50% ethanol solution, decolorize with activated carbon for 40 minutes, filter, cool down to crystallize, and vacuum dry to obtain pure potassium 2-hydroxy-4-methoxybenzoate. |
| Chemical Properties | Back Directory | [Melting point ]
>220°C (dec.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Cosmetics Ingredients Functions]
BLEACHING | [InChI]
InChI=1S/C8H8O4.K.H/c1-12-5-2-3-6(8(10)11)7(9)4-5;;/h2-4,9H,1H3,(H,10,11);; | [InChIKey]
YIKFQLYFPHZLOR-UHFFFAOYSA-N | [SMILES]
C(C1C=CC(OC)=CC=1O)(=O)O.[KH] | [CAS DataBase Reference]
152312-71-5 |
| Hazard Information | Back Directory | [Uses]
4MSK (Potassium 2-hydroxy-4-methoxybenzoate) inhibits the activity of the enzyme tyrosinase, which is needed for melanin production. It can be used to lighten and balance skin tone, and reducing dark spots or age spots.
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| Company Name: |
Beri Pharma Co., Ltd. Gold
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| Telephone: |
0756-8699456 13427714006 |
| Website: |
http://www.zhberi.com |
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