| Identification | Back Directory | [Name]
4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID | [CAS]
152529-79-8 | [Synonyms]
4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid
4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID
BENZENESULFONIC ACID,4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-
Benzenesulfonic acid, 4-(2,3,6,9-tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)- | [Molecular Formula]
C14H14N4O5S | [MDL Number]
MFCD06411605 | [MOL File]
152529-79-8.mol | [Molecular Weight]
350.35 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [density ]
1.522±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming | [form ]
Powder | [pka]
-1.59±0.50(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1]. | [Definition]
ChEBI: 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid is an oxopurine. | [in vivo]
PSB-1115 (0.5 mg/kg; i.p.; single dose, injected 20 minutes before inhalation) antagonizes the inhibitory effect of the non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2]. | [IC 50]
A2BR | [storage]
Store at RT | [References]
[1] Michael S, et al. Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. Purinergic Signal. 2010 Mar;6(1):117-24. DOI:10.1007/s11302-009-9174-y |
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