| Identification | Back Directory | [Name]
palitantin | [CAS]
15265-28-8 | [Synonyms]
palitantin
(-)-Palitantine
(2R)-2β-(Hydroxymethyl)-3α-[(1E,3E)-1,3-heptadienyl]-5β,6β-dihydroxycyclohexanone
(2R,3S,5R,6R)-rel-3-(1E,3E)-1,3-Heptadienyl-5,6-dihydroxy-2-(hydroxymethyl)-cyclohexanone
Cyclohexanone, 3-(1E,3E)-1,3-heptadien-1-yl-5,6-dihydroxy-2-(hydroxymethyl)-, (2R,3S,5R,6R)-rel- | [Molecular Formula]
C14H22O4 | [MOL File]
15265-28-8.mol | [Molecular Weight]
254.32 |
| Chemical Properties | Back Directory | [Melting point ]
169℃ (ethyl acetate ) | [alpha ]
235461 +4.4° (c = 0.8 in CHCl3) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
White solid. | [color ]
White |
| Hazard Information | Back Directory | [Description]
Palitantin is a fungal metabolite originally isolated from P. palitans. It inhibits HIV-1 integrase with IC50 values of 350 and 268 μM for 3’-processing and strand transfer activity, respectively. Palitantin has been used as a standard for dereplication of natural products. | [Uses]
Palitantin is an antifungal and antiprotozoal compound. | [IC 50]
Leishmania; Fungal Metabolite | [storage]
Store at -20°C | [References]
[1] J H BIRKINSHAW H R. Studies in the biochemistry of micro-organisms: Palitantin, C(14)H(22)O(4), a hitherto undescribed metabolic product of Penicillium palitans Westling.[J]. Biochemical Journal, 1936, 30 5: 801-808. DOI: 10.1042/bj0300801
[2] HUIXIAO HONG. Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching?[J]. Journal of Medicinal Chemistry, 1997, 40 6: 930-936. DOI: 10.1021/jm960754h
[3] KRISTIAN F. NIELSEN*. Dereplication of Microbial Natural Products by LC-DAD-TOFMS[J]. Journal of Natural Products , 2011, 74 11: 2338-2348. DOI: 10.1021/np200254t |
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