| Identification | Back Directory | [Name]
Bis-PEG6-NHS ester | [CAS]
1526718-98-8 | [Synonyms]
BIS-PEG6-NHS
4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C24H36N2O14 | [MDL Number]
MFCD24539464 | [MOL File]
1526718-98-8.mol | [Molecular Weight]
576.55 |
| Hazard Information | Back Directory | [Description]
Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Biological Activity]
Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Cleavable | PEGs | Alkyl/ether | |
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