| Identification | Back Directory | [Name]
5-(1-Methyl-1H-pyrazol-4-yl)-4-(4-morpholinyl)-7H-Pyrrolo[2,3-d]pyrimidine | [CAS]
1527473-30-8 | [Synonyms]
CS-2879 PF-06454589 PF-06454589 ;PF 06454589 ;PF06454589 5-(1-Methyl-1H-pyrazol-4-yl)-4-(4-morpholinyl)-7H-Pyrrolo[2,3-d]pyrimidine | [Molecular Formula]
C14H16N6O | [MDL Number]
MFCD28347839 | [MOL File]
1527473-30-8.mol | [Molecular Weight]
284.32 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
13.16±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1]. | [References]
[1] Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Ja DOI:10.1021/jm5014055 |
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