ChemicalBook--->CAS DataBase List--->1527473-30-8

1527473-30-8

1527473-30-8 Structure

1527473-30-8 Structure
IdentificationBack Directory
[Name]

5-(1-Methyl-1H-pyrazol-4-yl)-4-(4-morpholinyl)-7H-Pyrrolo[2,3-d]pyrimidine
[CAS]

1527473-30-8
[Synonyms]

CS-2879
PF-06454589
PF-06454589 ;PF 06454589 ;PF06454589
5-(1-Methyl-1H-pyrazol-4-yl)-4-(4-morpholinyl)-7H-Pyrrolo[2,3-d]pyrimidine
[Molecular Formula]

C14H16N6O
[MDL Number]

MFCD28347839
[MOL File]

1527473-30-8.mol
[Molecular Weight]

284.32
Chemical PropertiesBack Directory
[density ]

1.49±0.1 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: soluble10mg/mL, clear
[form ]

powder
[pka]

13.16±0.50(Predicted)
[color ]

white to beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
[Hazard Codes ]

Xn
[Risk Statements ]

22
Hazard InformationBack Directory
[Uses]

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].
[References]

[1] Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Ja DOI:10.1021/jm5014055
Spectrum DetailBack Directory
[Spectrum Detail]

5-(1-Methyl-1H-pyrazol-4-yl)-4-(4-morpholinyl)-7H-Pyrrolo[2,3-d]pyrimidine(1527473-30-8)1HNMR
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