| Identification | Back Directory | [Name]
(Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold | [CAS]
1527513-89-8 | [Synonyms]
TrxR inhibitor D9
(Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold | [Molecular Formula]
C25H21AuOPS | [MDL Number]
MFCD32899278 | [MOL File]
1527513-89-8.mol | [Molecular Weight]
597.44 |
| Hazard Information | Back Directory | [Uses]
(Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold is a potent thioredoxin reductase (TrxR) inhibitor. | [Biological Activity]
Cell permeable: yes''Primary Target
TrxR''Reversible: no | [in vivo]
TrxR inhibitor D9 (5 mg/kg; i.v. once every 2 d for 15 d) e?ectively inhibits the growth of tumors in mice[1]. | Animal Model: | BALB/c nude mice (17-18 g) bearing a MCF-7 tumor[1] | | Dosage: | 5 mg/kg | | Administration: | I.v. once every 2 days for 15 days | | Result: | Inhibited tumor growth with IR (inhibition ratio) of 91.5% and was well tolerated. |
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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