| Chemical Properties | Back Directory | [Boiling point ]
615.2±55.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.90±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
GNE-955 is a Potent Pan-Pim Inhibitor. GNE-955 is potent and has excellent bioavailability in rat. | [Uses]
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively. | [IC 50]
PIM1: 0.018 nM (Ki); PIM2: 0.11 nM (Ki); PIM3: 0.08 nM (Ki) | [References]
[1] Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60(10):4458-4473. DOI:10.1021/acs.jmedchem.7b00418 |
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