| Identification | Back Directory | [Name]
2H-Pyrrol-2-one, 4-chloro-1,5-dihydro-5-hydroxy-5-phenyl-1-(2-phenylethyl)- | [CAS]
1528760-09-9 | [Synonyms]
4-Chloro-5-hydroxy-1-phenethyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
2H-Pyrrol-2-one, 4-chloro-1,5-dihydro-5-hydroxy-5-phenyl-1-(2-phenylethyl)- | [Molecular Formula]
C18H16ClNO2 | [MOL File]
1528760-09-9.mol | [Molecular Weight]
313.78 |
| Chemical Properties | Back Directory | [Boiling point ]
541.4±50.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.15±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PNB-001 is an orally active CCK2 selective ligand and antagonist. PNB-001 has anti-inflammatory and analgesic activities[1]. | [in vivo]
PNB-001 (5 and 20 mg /kg, p.o.) shows anti-inflammatory activity, and protects rats against Indomethacin (HY-14397) induced ulceration[1].
| [References]
[1] Lattmann E, et al. Cholecystokinin-2/gastrin antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anti-inflammatory analgesics for the treatment of inflammatory bowel disease. Medchemcomm. 2017 Feb 17;8(3):680-685. DOI:10.1039/c6md00707d |
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