| Identification | Back Directory | [Name]
(E)-3-(4-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one | [CAS]
152897-41-1 | [Synonyms]
MAO-B-IN-19
(E)-3-(4-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one, 3-(4-fluorophenyl)-1-(2-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C15H11FO2 | [MDL Number]
MFCD00016446 | [MOL File]
152897-41-1.mol | [Molecular Weight]
242.24 |
| Chemical Properties | Back Directory | [Melting point ]
117-118 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
394.8±42.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [pka]
7.79±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50?of?0.67?μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties[1]. | [IC 50]
MAO-B: 0.67 μM (IC50) | [References]
[1] Rui Chen, et al. Development of the "hidden" multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 May 5;251:115253. DOI:10.1016/j.ejmech.2023.115253 |
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