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152918-26-8

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152918-26-8 Structure

152918-26-8 Structure
IdentificationBack Directory
[Name]

N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine
[CAS]

152918-26-8
[Synonyms]

ABMECA,AB MECA
AB-MECA HIGH AFFINITY A3 ADEN
N6-(4-AMINOBENZYL)-N-METHYLCARBOXAMIDOADENOSINE
n6-(4-aminobenzyl)-9-[5-(methylcarbonyl)-β-d-ribofuranosyl]adenine
β-D-Ribofuranuronamide, 1-[6-[[(4-aminophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-
N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine, N6-(4-Aminobenzyl)-9-[5-(methylcarbonyl)-β-D-ribofuranosyl]adenine
[Molecular Formula]

C18H21N7O4
[MDL Number]

MFCD05861375
[MOL File]

152918-26-8.mol
[Molecular Weight]

399.4
Chemical PropertiesBack Directory
[density ]

1.68±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.3mg/mL
[form ]

solid
[pka]

12.72±0.70(Predicted)
[color ]

off-white
[Water Solubility ]

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3mg/mL
ethanol: 1mg/mL
DMSO: 10mg/mL
dilute aqueous base: 3.5mg/mL
H2O: insoluble
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

AB-MECA is a high affinity A3 adenosine receptor agonist.
[Biochem/physiol Actions]

High affinity A3 adenosine receptor agonist.
[in vivo]

AB-MECA (3 ug/kg; iv) enhances plasma histamine level in mouse[4].
AB-MECA (0.3 mg/kg; iv) enhances antigen-induced bronchoconstriction in male albino guinea pigs, weighing 180-220 g[5].

Animal Model:Male Balb/c mice, weighing 18-25 g[4]
Dosage:3 ug/kg
Administration:IV; single dose
Result:Induced a 5.9-fold increase in histamine levels in murine plasma.
[IC 50]

Adenosine A3 receptor
[storage]

Store at -20°C
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