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18-Azido-stearic acid is a click chemistry reagent containing an azide group. 18-Azido-stearic acid can be used as a hydrophobic bioconjugation linker (using N-Myristoyltransferase) that can be further modified at the azido-position using Click-chemistry[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [References]
[1] Ejendal KFK, et al. Protein Labeling and Bioconjugation Using N-Myristoyltransferase. Methods Mol Biol. 2019;2033:149-165. DOI:10.1007/978-1-4939-9654-4_11 |
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