| Hazard Information | Back Directory | [Description]
PPT is a modulator of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. | [Uses]
Personalised postprandial-targeting is a way to modulate water-heme interactions with activity against low-spin P450 complexes. Personalised postprandial-targeting is able to maintain the axial water ligands of CYP2C9 even in the presence of inhibitors. Personalised postprandial-targeting also allows the hydrogen atoms of the axial water ligands to be observed by EPR spectroscopy, providing insights into the enzyme active site[1]. | [References]
[1] Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1 |
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