| Identification | Back Directory | [Name]
PD 145065 | [CAS]
153049-49-1 | [Synonyms]
PD 145065
Ac-bhg-Leu-Asp-Ile-Ile-Trp
AC-DBHG-LEU-ASP-ILE-ILE-TRP
AC-D-BHG-LEU-ASP-ILE-ILE-TRP-OH
[AC-DBHG16] ENDOTHELIN-1 (16-21)
endothelin receptor antagonist*pd 145065
N-Acetyl-α-[10,11-Dihydro-5H-dibenzo[a,d]cycloheptadien-5-yl]-D-Gly-Leu-Asp-Ile-Ile-Trp
L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-α-aspartyl]-L-isoleucyl]-L-isoleucyl]- (9CI) | [Molecular Formula]
C52H67N7O10 | [MDL Number]
MFCD00467202 | [MOL File]
153049-49-1.mol | [Molecular Weight]
950.13 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
phosphate buffer, pH 7.5: 1mg/mL | [form ]
White solid | [color ]
white | [Sequence]
Ac-{D-Bhg}-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine) | [InChIKey]
HRAQSWKGRRUBDJ-OMUAVVNCSA-N |
| Hazard Information | Back Directory | [Uses]
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1]. | [Biological Activity]
Cell permeable: no''Primary Target
Endothelin receptor antagonist''Product does not compete with ATP.''Reversible: no''Target IC50: 4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (r at cerebellum) | [References]
[1] Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DOI:10.1111/j.1476-5381.1994.tb13053.x |
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Merck KGaA
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Fuan Bio
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