| Identification | Back Directory | [Name]
1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE | [CAS]
15317-58-5 | [Synonyms]
AKOS B000103
AKOS BC-1552
BUTTPARK 148\07-47
CHEMBRDG-BB 3000103
TIMTEC-BB SBB009151
ART-CHEM-BB B000103
1H-INDOLE-3-CARBOHYDRAZIDE
Indole-3-carboxylic acid hydrazide
1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE
1H-indole-3-carbohydrazide(SALTDATA: FREE) | [Molecular Formula]
C9H9N3O | [MDL Number]
MFCD00464063 | [MOL File]
15317-58-5.mol | [Molecular Weight]
175.19 |
| Chemical Properties | Back Directory | [Melting point ]
224-226 °C (decomp) | [density ]
1.353±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Sparingly), Ethanol (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
13.07±0.30(Predicted) | [color ]
Pale Yellow to Pale Beige |
| Hazard Information | Back Directory | [Synthesis]
GENERAL PROCEDURE: Methyl indole-3-carboxylate (5 mmol) was slowly added to hydrazine hydrate (80%, 3 mL) at room temperature. Subsequently, the reaction mixture was subjected to continuous microwave irradiation at 300 W for 5-8 min. The reaction process was monitored by thin layer chromatography (TLC). Once the reaction was complete, the mixture was cooled sufficiently to room temperature to afford the intermediate indole-3-carbohydrazide in 83-98% yield. | [References]
[1] Journal of Chemical Research, 2015, vol. 39, # 5, p. 296 - 299
[2] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 22 - 32
[3] Chemistry of Heterocyclic Compounds, 1982, vol. 18, # 3, p. 258 - 261
[4] Pharmazie, 2017, vol. 72, # 12, p. 707 - 713
[5] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 10, p. 1270 - 1275 |
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