| Identification | Back Directory | [Name]
AurkinA | [CAS]
1534060-58-6 | [Synonyms]
AurkinA 2-(3-Bromophenyl)-8-fluoro-4-quinolinecarboxylicacid 4-Quinolinecarboxylic acid, 2-(3-bromophenyl)-8-fluoro- | [Molecular Formula]
C16H9BrFNO2 | [MDL Number]
MFCD31714169 | [MOL File]
1534060-58-6.mol | [Molecular Weight]
346.15 |
| Chemical Properties | Back Directory | [Boiling point ]
490.6±45.0 °C(Predicted) | [density ]
1.610±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.12±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM [1]. | [IC 50]
Aurora A: 3.77 μM (Kd) | [References]
[1] Jane?ek M, et al., Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep. 2016 Jun 24;6:28528. DOI:10.1038/srep28528 |
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