ChemicalBook--->CAS DataBase List--->1534060-58-6

1534060-58-6

1534060-58-6 Structure

1534060-58-6 Structure
IdentificationBack Directory
[Name]

AurkinA
[CAS]

1534060-58-6
[Synonyms]

AurkinA
2-(3-Bromophenyl)-8-fluoro-4-quinolinecarboxylicacid
4-Quinolinecarboxylic acid, 2-(3-bromophenyl)-8-fluoro-
[Molecular Formula]

C16H9BrFNO2
[MDL Number]

MFCD31714169
[MOL File]

1534060-58-6.mol
[Molecular Weight]

346.15
Chemical PropertiesBack Directory
[Boiling point ]

490.6±45.0 °C(Predicted)
[density ]

1.610±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

2.12±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM [1].
[IC 50]

Aurora A: 3.77 μM (Kd)
[References]

[1] Jane?ek M, et al., Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep. 2016 Jun 24;6:28528. DOI:10.1038/srep28528
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