| Identification | Back Directory | [Name]
ZD 9331 | [CAS]
153537-74-7 | [Synonyms]
(R)-BGC9331
(R)-ZD 9331
(R)-Plevitrexed
Plevitrexed ((R)-isoMer)
IEJSCSAMMLUINT-OAQYLSRUSA-N | [Molecular Formula]
C26H25FN8O4 | [MDL Number]
MFCD32664448 | [MOL File]
153537-74-7.mol | [Molecular Weight]
532.526 |
| Hazard Information | Back Directory | [Uses]
(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor[2]. (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Marsham PR, et al. Design?and?synthesis?of?potent?non-polyglutamatable?quinazoline?antifolatethymidylate?synthase?inhibitors. J Med Chem.?1999 Sep 23;42(19):3809-20. DOI:10.1021/jm9803727
[2] Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem.?2013?Jul 11;56(13):5446-55. DOI:10.1021/jm400490e |
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