| Identification | Back Directory | [Name]
L-Alanine, N-[[2-[(2-chloroacetyl)amino]ethoxy](5'-guanylyloxy)phosphinyl]-, 1-(2-propylpentyl) ester | [CAS]
1536470-98-0 | [Synonyms]
L-Alanine, N-[[2-[(2-chloroacetyl)amino]ethoxy](5'-guanylyloxy)phosphinyl]-, 1-(2-propylpentyl) ester | [Molecular Formula]
C25H42ClN7O13P2 | [MOL File]
1536470-98-0.mol | [Molecular Weight]
746.04 |
| Hazard Information | Back Directory | [Description]
SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C. | [Uses]
SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM[1]. | [References]
[1] Lim SM, et al., Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. DOI:10.1002/anie.201307387 |
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