| Identification | Back Directory | [Name]
2-ethynylpyrazine | [CAS]
153800-11-4 | [Synonyms]
2-ethynylpyrazine
Pyrazine, 2-ethynyl-
2-Ethynylpyrazine 98%
2-Ethynyl-1,4-diazine, (Pyrazin-2-yl)acetylene | [Molecular Formula]
C6H4N2 | [MDL Number]
MFCD13189804 | [MOL File]
153800-11-4.mol | [Molecular Weight]
104.11 |
| Chemical Properties | Back Directory | [Boiling point ]
180.3±20.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
crystalline solid | [pka]
-0.40±0.10(Predicted) | [color ]
Light gold to faint brown |
| Hazard Information | Back Directory | [Synthesis]
To a solution of compound (CAS:291763-66-1) (3.0 g, 17.02 mmol) in THF (10 mL) was slowly added 1 M TBAF (tetrabutylammonium fluoride) solution over 9 min. The progress of the reaction was monitored by TLC (Thin Layer Chromatography) to confirm the complete conversion of the feedstock to the target product 2-alkynylpyrazines. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to give 2-alkynylpyrazines (1.0 g, yield: 56.5%). LC-MS (Liquid Chromatography-Mass Spectrometry) analysis showed: m/z 105 ([M+H]+). | [References]
[1] Patent: WO2017/117708, 2017, A1. Location in patent: Page/Page column 18; 19
[2] Patent: WO2017/93544, 2017, A1. Location in patent: Page/Page column 97; 98
[3] Carbohydrate Research, 2011, vol. 346, # 9, p. 1083 - 1092
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 3033 - 3047
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3532 - 3548 |
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