| Chemical Properties | Back Directory | [Boiling point ]
811.2±75.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: insol; DMSO: 10 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | [form ]
A solid | [pka]
9.12±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Piperazine-Erastin is an erastin derivative. It acts by inducing ferroptosis in cancer cells. | [Uses]
Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. Piperazine erastin can be used in cancer research[1]. | [in vivo]
In the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kg piperazine erastin administration[1]. | [References]
[1] Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331. DOI:10.1016/j.cell.2013.12.010 |
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