| Identification | Back Directory | [Name]
tert-butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate | [CAS]
1539292-60-8 | [Synonyms]
AUN 92608
APN-C3-NH-Boc
tert-butyl 3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylcarbamate | [Molecular Formula]
C18H21N3O3 | [MDL Number]
MFCD31561122 | [MOL File]
1539292-60-8.mol | [Molecular Weight]
327.38 |
| Hazard Information | Back Directory | [Description]
APN-NH-Boc is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Boc group. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation. | [Uses]
APN-C3-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. APN-C3-NH-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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