| Identification | Back Directory | [Name]
Pep2-8 | [CAS]
1541011-97-5 | [Synonyms]
Pep2-8
(3S,6S,9S,12S,15S)-15-((2S,5S,8S,11S,14S,17S)-2-((1H-Indol-3-yl)methyl)-11-benzyl-8,17-bis((R)-1-hydroxyethyl)-5-(hydroxymethyl)-14-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosanamido)-3-(((S)-1-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino
(3S,6S,9S,12S,15S)-15-((2S,5S,8S,11S,14S,17S)-2-((1H-Indol-3-yl)methyl)-11-benzyl-8,17-bis((R)-1-hydroxyethyl)-5-(hydroxymethyl)-14-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosanamido)-3-(((S)-1-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-12-(2-carboxyethyl)-9-(4-hydroxybenzyl)-6-isobutyl-5,8,11,14-tetraoxo-4,7,10,13-tetraazaoctadecane-1,18-dioic acid | [Molecular Formula]
C83H110N16O24 | [MOL File]
1541011-97-5.mol | [Molecular Weight]
1715.88 |
| Chemical Properties | Back Directory | [Boiling point ]
2059.4±65.0 °C(Predicted) | [density ]
1.357±0.06 g/cm3(Predicted) | [storage temp. ]
store at -20°C, protect from light | [solubility ]
Soluble 2mg/mL in PBS (pH 7.4) | [form ]
A solid | [pka]
4.20±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 |
| Hazard Information | Back Directory | [Uses]
Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM[1]. | [storage]
Store at -20°C | [References]
[1] Yingnan Zhang, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014 Jan 10;289(2):942-55. DOI:10.1074/jbc.M113.514067 |
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