| Identification | Back Directory | [Name]
KH176) | [CAS]
1541170-75-5 | [Synonyms]
KH176)
Sonlicromanol
KH-176
(Sonlicromanol
2H-1-Benzopyran-2-carboxamide, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-N-(3R)-3-piperidinyl-, (2S)- | [Molecular Formula]
C19H28N2O3 | [MDL Number]
MFCD34469312 | [MOL File]
1541170-75-5.mol | [Molecular Weight]
332.44 |
| Chemical Properties | Back Directory | [Boiling point ]
570.8±50.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.29±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2]. | [in vivo]
Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases[3]. | Animal Model: | Ndufs4?/? mice[3]. | | Dosage: | 10 mg/kg. | | Administration: | Twice daily by intraperitoneal injection. | | Result: | Increased lifespan of Ndufs4?/? mice similar as KH176 and Clofibrate single treatment. |
| [References]
[1] X Jiang, et al. Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE 2 biosynthesis by sonlicromanol's metabolite KH176m. Sci Rep. 2021 Jan 13;11(1):880. DOI:10.1038/s41598-020-79466-w
[2] Zikai Feng, et al. Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones. Pharmaceuticals (Basel). 2020 Aug 7;13(8):184. DOI:10.3390/ph13080184
[3] Sanne J C M Frambach, et al. Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165727. DOI:10.1016/j.bbadis.2020.165727 |
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