| Hazard Information | Back Directory | [Description]
ST7710AA1 is a PARP-1 inhibitor. It acts by showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp. | [Uses]
ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC50 value of 0.07 μM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity[1]. | [in vivo]
ST7710AA1 (100 mg/kg; i.p.; every 2 days for 2 weeks) shows antitumor activity in mice[1]. | [IC 50]
PARP-1: 0.07 μM (IC50) | [References]
[1] Cincinelli R, et al. 7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors. Bioorg Med Chem. 2014 Feb 1;22(3):1089-103. DOI:10.1016/j.bmc.2013.12.031 |
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