| Identification | Back Directory | [Name]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE | [CAS]
154436-49-4 | [Synonyms]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
5,8,11,13-Eicosatetraenoic acid, 15-hydroperoxy-, 2-[[(2-aminoethoxy)hydroxyphosphinyl]oxy]-1-[[(1-oxooctadecyl)oxy]methyl]ethyl ester, [S-[R*,S*-(E,Z,Z,Z)]]- (9CI) | [Molecular Formula]
C43H78NO10P | [MOL File]
154436-49-4.mol | [Molecular Weight]
800.07 |
| Chemical Properties | Back Directory | [Boiling point ]
824.5±75.0 °C(Predicted) | [density ]
1.049±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml | [pka]
1.17±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE; ) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3. | [Uses]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3. | [References]
[1] Kagan, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13(1), 81-90 (2017). |
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