| Identification | Back Directory | [Name]
4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide | [CAS]
154540-49-5 | [Synonyms]
fluoroclebopride
4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide
Benzamide,4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy- | [Molecular Formula]
C20H23ClFN3O2 | [MOL File]
154540-49-5.mol | [Molecular Weight]
391.87 |
| Chemical Properties | Back Directory | [Boiling point ]
518.2±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
13.62±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1, serotonin 5-HT2, and α2-adrenergic receptors (Kis = >10,000, 283, and 1,300 nM, respectively). A fluorine-18 moiety has been used to label this compound for use as a probe for studying D2/D3 receptor availability via PET in various monkey models. | [Uses]
Fluoroclebopride binds reversibly to dopamine receptors. 18F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models[1][2]. | [storage]
Store at -20°C | [References]
[1] Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162(8):1473-82. DOI:10.1176/appi.ajp.162.8.1473
[2] Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29:10.1007/s00213-013-3274-7. DOI:10.1007/s00213-013-3274-7. doi: 10.1007/s00213-013-3274-7 |
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D&C Chemicals
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