| Identification | Back Directory | [Name]
methyl brevifolincarboxylate | [CAS]
154702-76-8 | [Synonyms]
methyl brevifolincarboxylate
methyl brevifolincarboxylate USP/EP/BP
methyl 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylate
Cyclopenta[c][2]benzopyran-1-carboxylic acid, 1,2,3,5-tetrahydro-7,8,9-trihydroxy-3,5-dioxo-, methyl ester | [Molecular Formula]
C14H10O8 | [MOL File]
154702-76-8.mol | [Molecular Weight]
306.22 |
| Hazard Information | Back Directory | [Uses]
Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation[1][2][4][5][6]. | [Definition]
ChEBI: An organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from Phyll
nthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity. | [Synthesis]
Extraction method of short-leaf hematoxylin methyl ester: take dry leaves under the beads of the whole grass, beaten into coarse powder, placed into the Sojitz extractor, first add petroleum ether degreasing, the dregs of the drug cool dry, and then fully | [storage]
Store at -20°C | [References]
[1] Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. DOI:10.3390/ijms12128740
[2] Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340. DOI:10.1016/j.jep.2007.11.040
[3] Iizuka T, et al. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9. DOI:10.1248/bpb.29.177
[4] Iizuka T, et al. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4. DOI:10.1248/bpb.30.382 |
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