| Identification | Back Directory | [Name]
1-Azoniabicyclo[2.2.2]octane,1-[2-[(3R)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-,chloride (1:1) | [CAS]
154728-59-3 | [Synonyms]
SR140603
SR-140603
SR 140603
(R)-Nolpitantium Chloride
1-Azoniabicyclo[2.2.2]octane,1-[2-[(3R)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-,chloride (1:1) | [Molecular Formula]
C37H45Cl3N2O2 | [MOL File]
154728-59-3.mol | [Molecular Weight]
656.124 |
| Hazard Information | Back Directory | [Description]
SR-140603 is the less potent enantiomer of SR 140333, used as the negative control. | [Uses]
(R)-Nolpitantium is the R-enantiomer of Nolpitantium (HY-108479). Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1]. | [References]
[1] Oury-Donat F, et al. SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J Neurochem. 1994 Apr;62(4):1399-407. DOI:10.1046/j.1471-4159.1994.62041399.x |
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