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PNU-145156E (FCE26644) is an angiogenesis inhibitor with anti-tumor activity. PNU-145156E inhibits the binding of bFGF to its receptor and inhibits bFGF-induced endothelial cell proliferation and motility[1]. | [References]
[1] Groen H J M, et al. PNU-145156E, a novel angiogenesis inhibitor, in patients with solid tumors: a phase I and pharmacokinetic study[J]. Clinical cancer research, 2001, 7(12): 3928-3933. PMID:11751484 |
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