| Hazard Information | Back Directory | [Description]
BRD4097 is a negative control in HDAC1/2/3/8 assays | [Uses]
BRD4097 is an inhibitor of histone deacetylase (HDAC). BRD4097 acts by inhibiting the activity of HDACs, especially HDAC 1,2 and 3, through metal chelation and spatial rejection mechanisms, and this inhibition may help regulate gene expression and alter chromatin structure, thereby affecting a variety of biological processes. BRD4097 is used to study the role of HDAC in cholesterol metabolism and NPC1 diseases[1]. | [References]
[1] Cruz D L, et al. Inhibition of histone deacetylases 1, 2, and 3 enhances clearance of cholesterol accumulation in Niemann-Pick C1 fibroblasts[J]. ACS Pharmacology & Translational Science, 2021, 4(3): 1136-1148. DOI:10.1021/acsptsci.1c00033 |
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