| Identification | Back Directory | [Name]
Emodepside | [CAS]
155030-63-0 | [Synonyms]
QHT06
Emodepside
PF 1022-221
Bay 44-4400
Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzeneprop
Cyclo[(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]
Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl | [Molecular Formula]
C60H90N6O14 | [MDL Number]
MFCD09837720 | [MOL File]
155030-63-0.mol | [Molecular Weight]
1119.39 |
| Chemical Properties | Back Directory | [Boiling point ]
1219.3±65.0 °C(Predicted) | [density ]
1.104±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : ≥ 31 mg/mL (27.69 mM) | [form ]
Solid | [pka]
5.34±0.40(Predicted) | [color ]
White to off-white | [InChIKey]
ZMQMTKVVAMWKNY-FYSVEKGBNA-N |
| Hazard Information | Back Directory | [Uses]
Emodepside-d6 is an isotopic labeled compound of Emodepside; an anthelmintic drug very active against gastrointestinal nematodes. | [Definition]
ChEBI: A cyclooctadepsipeptide consisting of D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, N-methyl-L-leucyl, D-lact
yl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, and N-methyl-L-leucyl residues joined in sequence to give a 24-membered macrocycle. An anthelmintic, it i
used with praziquantel for the treatment and control of hookworm, roundworm and tapeworm infections in cats. | [Biological Activity]
Emodepside is a cyclooctadepsipeptide anthelmintic a novel mode of action involving the calcium-gated potassium channel SLO-1 in C. eleganssometimes mediated by a latrophilin (LAT) receptor. | [Veterinary Drugs and Treatments]
Emodepside/Praziquantel topical solution (Profender?) is indicated
for the treatment and control of hookworm infections caused by
Ancylostoma tubaeforme (adults, immature adults, and fourth stage
larvae), roundworm infections caused by Toxocara cati (adults and
fourth stage larvae), and tapeworm infections caused by Dipylidium
caninum (adults) and Taenia taeniaeformis (adults) in cats. | [in vivo]
Emodepside interferes with signaling at the neuromuscular junction on the body-wall muscles, pharynx and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction[4]. | [storage]
Store at -20°C |
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