| Identification | Back Directory | [Name]
7-[[6-O-(2-Carboxyacetyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one | [CAS]
155049-92-6 | [Synonyms]
Acacetin-7-O-6''-Malonylglucoside
7-[[6-O-(2-Carboxyacetyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one | [Molecular Formula]
C25H24O13 | [MOL File]
155049-92-6.mol | [Molecular Weight]
532.45 |
| Chemical Properties | Back Directory | [Boiling point ]
848.2±65.0 °C(Predicted) | [density ]
1.571±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
2.70±0.32(Predicted) |
| Hazard Information | Back Directory | [Uses]
Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values ??of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders[1]. | [IC 50]
MAO-A: 2.34 μM (IC50); MAO-B: 1.87 μM (IC50) | [References]
[1] Lee H W, et al. Potent inhibitions of monoamine oxidase A and B by acacetin and its 7-O-(6-O-malonylglucoside) derivative from Agastache rugosa[J]. International journal of biological macromolecules, 2017, 104: 547-553. DOI:10.1016/j.ijbiomac.2017.06.076 |
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