ChemicalBook--->CAS DataBase List--->1553977-42-6

1553977-42-6

1553977-42-6 Structure

1553977-42-6 Structure
IdentificationBack Directory
[Name]

Btk inhibitor 1 (R enantioMer hydrochloride)
[CAS]

1553977-42-6
[Synonyms]

IBT6A hydrochloride
Btk inhibitor 1 R enantiomer HCl
Btk inhibitor 1 (R enantioMer hydrochloride)
BTK INHIBITOR 1 R ENANTIOMER HYDROCHLORIDE (IBRUTINIB ANALOG HYDROCHLORIDE)
3-(4-Phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride (1:1)
[Molecular Formula]

C22H23ClN6O
[MOL File]

1553977-42-6.mol
[Molecular Weight]

422.911
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Btk inhibitor 1R enantiomer Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.IC50 value:Target: BtkFrom PCT Int. Appl. (2012), WO 2012158843 A2 20121122.

[Uses]

IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].
[storage]

Store at -20°C
[References]

[1]. PCT Int. Appl. (2012), WO 2012158843 A2 20121122.

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