| Identification | Back Directory | [Name]
BNC375 | [CAS]
1557240-80-8 | [Synonyms]
BNC375
BNC375,BNC-375
Benzenesulfonamide, 4-[(1R,3R)-3-[[(5-chloro-2-methoxyphenyl)amino]methyl]-2,2-dimethylcyclopropyl]- | [Molecular Formula]
C19H23ClN2O3S | [MDL Number]
MFCD32067957 | [MOL File]
1557240-80-8.mol | [Molecular Weight]
394.92 |
| Chemical Properties | Back Directory | [Boiling point ]
553.9±60.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.19±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375 exhibits good CNS-agent like properties and clinical candidate potential. [1]. | [in vivo]
BNC375 (0.003-10.0 mg/kg, administered orally) exhibits the MED of 0.03 mg/kg, and achieves full reversal of the Scopolamine-induced impairment at 1.0 mg/kg in mouse T-maze model. BNC375 exhibits the plasm half-life (t1/2) of 1.2 h[1]. | [References]
[1] Andrew J Harvey, et al. Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. ACS Med Chem Lett. 2019 Mar 25;10(5):754-760. DOI:10.1021/acsmedchemlett.9b00001 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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