| Identification | Back Directory | [Name]
4-IBP | [CAS]
155798-08-6 | [Synonyms]
4-IBP
4 IBP;4IBP
N-(N-BENZYLPIPERIDIN-4-YL)-4-IODOBENZAMIDE
N-(1-benzyl-4-piperidinyl)-4-iodobenzamide
Benzamide, 4-iodo-N-[1-(phenylmethyl)-4-piperidinyl]- | [Molecular Formula]
C19H21IN2O | [MDL Number]
MFCD00673910 | [MOL File]
155798-08-6.mol | [Molecular Weight]
420.29 |
| Chemical Properties | Back Directory | [Melting point ]
196-197 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
516.5±50.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO : 20 mg/mL (47.59 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
13.94±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Pretreatment with 4-IBP, which is a sigma-?one receptor (σ1R) agonist, blocked spreading depression (SD). | [Definition]
ChEBI: 4-iodo-N-[1-(phenylmethyl)-4-piperidinyl]benzamide is a member of piperidines. | [Biological Activity]
Combines high affinity for σ 1 and moderate affinity for σ 2 sites. Centrally active following systemic administration in vivo . | [IC 50]
Sigma 1 Receptor; Sigma 2 Receptor | [storage]
Store at -20°C |
|
|