| Identification | Back Directory | [Name]
TP0463518 | [CAS]
1558021-37-6 | [Synonyms]
BGE-117
TP0463518
Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]- | [Molecular Formula]
C20H18ClN3O6 | [MOL File]
1558021-37-6.mol | [Molecular Weight]
431.83 |
| Chemical Properties | Back Directory | [Boiling point ]
775.8±60.0 °C(Predicted) | [density ]
1.512±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:40.0(Max Conc. mg/mL);92.63(Max Conc. mM) | [form ]
A solid | [pka]
3.63±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1]. | [storage]
Store at -20°C | [References]
[1] Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144. DOI:10.1016/j.ejphar.2018.08.044 |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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